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Zopiclone is thoroughly and quickly metabolised via the liver. A large number of metabolites are actually isolated and characterised, Using the two significant types staying the N-oxide, produced by oxidation in the piperazine nitrogen and the N-desmethyl made by oxidative demethylation on the N-methyl piperazine. Just the N-oxide analogue has weak pharmacological exercise.
The potential risk of dependence or abuse increases with dose and length of procedure. Situations of dependence are actually documented a lot more frequently in sufferers dealt with with zopiclone for for a longer time than four months. The chance of abuse or dependence is also increased in people with a record of psychiatric Issues and/or Liquor or drug abuse.
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Bardzo rzadko: zwiększenie aktywności enzymów wątrobowych oraz fosfatazy alkalicznej, reakcje nadwrażliwości, w tym obrzęk naczynioruchowy i reakcje click here anafilaktyczne.
Warning needs to be exercised in administering zopiclone to people today recognized for being habit susceptible or All those whose historical past implies They could boost the dosage on their own initiative.
Zmniejszenie dawki może być konieczne w przypadku jednoczesnego stosowania z lekami działającymi hamująco na ośrodkowy United kingdomład nerwowy.
For the reason that Imovane will make you sleepy, you should not run harmful machinery or drive motor motor vehicles for twelve hrs When you choose it. It's also wise to be careful the next morning any time you get up.
Pamiętaj, że oczekiwane korzyści ze stosowania leku są z reguły większe, niż szkody wynikające z pojawienia się działań niepożądanych.
Exceptional instances of angioedema involving the tongue, glottis or larynx happen to be claimed in patients right after taking the main or subsequent doses of sedative-hypnotics, like zopiclone. Some individuals have had extra indicators for example dyspnoea, throat closing, or nausea and vomiting that recommend anaphylaxis.
Z-hypnotika er benzodiazdepinlignende sovemidler. I Norge har vi to typer på markedet som er omtrent like i virkning og bivirkninger:
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De får derimot en toleranseutvikling og avhengighet med bivirkninger som likner på dem vi kjenner fra benzodiazepinene.
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